If you didn’t get a chance to tune into this weeks interview, be sure to download this pod cast!
It was my pleasure to interview Dr. David R. Bundle.
Education.
Dr. Bundle Received his B.Sc. from University of Nottingham, and His Ph.D from The University of Newcastle. Shortly there after Dr. Bundle came across the Pond to work with Dr. Raymond U. Lemieux.
Research Initiatives.
Dr. Bundle’s lab is focused on many different projects. However one of the most recent is the topic within his most recent scientific publication. From the PNAS paper titled “In Vivo supramolecular templating enhances the activity of multivalent ligands: A potential therapeutic against the Escherichia Coli 0157 AB5 toxins”. This article holds particular water as it describes a technique developed By Dr. Bundle & Pavel Kitov. This has just received funding from the Gates foundation to cure Cholera, A world wide epidemic!
Dr. Bundle’s lab is of course working on many other projects and here are a few…
- The development of a biosensor based on self assembled monolayers that present covalently attached oligosaccharides.
- "Targeted Cancer Vaccines: Synthesis and Evaluation of Clustered Melanoma Antigens."
- "Synthetic oligosaccharides and neutralization of ganglioside antibodies"
- "Candida albicans Conjugate Vaccines: Evaluation of synthetic beta-mannan oligosaccharides conjugated to immunogenic carriers in rabbit and mouse models of experimental candidiasis."
- "Design and Synthesis of Drugs to Treat Alzheimer Disease by Reduction of Serum Amyloid Protein and Amyloid Deposits."
By utilizing multiple disciplines such as mass spec and crystallography, Dr. Bundle is able to specifically map compounds and create such molecules as the one used in his recent article for Ecoli…
And be sure to check out the link to the Alberta Ingenuity center. Where Dr. Bundle and colleagues are teamed up to really tackle the top issues within the field!
Be sure to listen to the interview of Dr. Bundle He is one of our most engaging interviews and is simply up to some of the best research out there!!
Here are a few links of interest or Dr. Bundle
http://www.chem.ualberta.ca/faculty_staff/faculty/bundle.html
http://www.chem.ualberta.ca/~glyco/
http://www.chem.ualberta.ca/about.html
http://www.carbohydratecentre.ualberta.ca/bundle.cfm
http://www.carbohydratecentre.ualberta.ca/index.cfm
http://www.theracarb.com/documents/TheracarbPressRelease_102007.pdf
http://www.pnas.org/content/105/44/16837
